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dc.contributor.authorGarcía Denegri, María Emilia
dc.contributor.authorTeibler, Gladys Pamela
dc.contributor.authorMaruñak, Silvana L.
dc.contributor.authorHernández, David Roque
dc.contributor.authorAcosta, Ofelia Cristina
dc.contributor.authorLeiva, Laura Cristina
dc.date.accessioned2021-12-13T17:06:08Z
dc.date.available2021-12-13T17:06:08Z
dc.date.issued2016
dc.identifier.citationGarcía Denegri, María Emilia, et al., 2016. Efficient muscle regeneration after highly haemorrhagic bothrops alternatus venom injection. Toxicon. San Diego: Elsevier, vol. 122, p. 167-175. ISSN 0041-0101.es
dc.identifier.issn0041-0101es
dc.identifier.urihttp://repositorio.unne.edu.ar/handle/123456789/30352
dc.description.abstractBothrops alternatus snake venom is particularly characterized for inducing a prominent haemorrhage and affecting hemostasis as a consequence of 43.1% of metallo-proteinases and less than 10% of PLA2 (almost all non-myotoxic phospholipases) in its venomics. In addition, myonecrosis is the major local effect in viper envenoming which might lead to permanent sequela. Then, the rebuilding of the microvasculature at the local injured site acquires significance since represents one of the pivotal stages for subsequent skeletal muscle regeneration either at morphological or functional aspects. Due to the significance played by vasculature in this process, it is important to study by histology and immunohistochemical tech niques, the muscular damage and the sequence of skeletal muscle reconstruction (degree of damage, reconstitution of muscle fibres and capillaries). In this work, we injected intramuscularly 50 or 100 mg per mouse of B. alternatus venom in gastrocnemius muscles. We provided a complete description and characterization of the different stages of myogenesis after mild (50 mg) and severe (100 mg) local injury induced by B. alternatus venom toxins. The regeneration was evaluated 24 h, 3, 7, 14 and 28 days after receiving venom injection. Finally, both doses induced an extended necrosis at the site of injection where, when critical steps in the regenerative process are taking place, an efficient tissue rebuilding is achieved. B. alternatus venom is characterized by the high percentage of exclusively class P-III metal loproteinases, and by the lack of class P-I metalloproteinases in its venom composition. This could explain the effectiveness of muscle regeneration after venom injection despite the severity of the initial phase of envenoming.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rightsopenAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/es
dc.sourceToxicon, 2016, vol. 122, p. 167-175.es
dc.subjectEfficientes
dc.subjectHaemorrhagices
dc.subjectvenomes
dc.titleEfficient muscle regeneration after highly haemorrhagic bothrops alternatus venom injectiones
dc.typeArtículoes
unne.affiliationFil: García Denegri, María Emilia. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina.es
unne.affiliationFil: Teibler, Gladys Pamela. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina.es
unne.affiliationFil: Maruñak, Silvana Licia. Universidad Nacional del Nordeste. Facultad de Ciencias. Veterinarias; Argentinaes
unne.affiliationFil: Hernández, David Roque. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina.es
unne.affiliationFil: Acosta, Ofelia Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina.es
unne.affiliationFil: Leiva, Laura Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura; Argentina.es
unne.journal.paisEstados Unidoses
unne.journal.ciudadSan Diegoes


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