South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review

Abstract

In South America there are three snake genera with predominantly neurotoxic venoms: Crotalus, Micrurus and Hydrophis, which include nine species/subspecies, 97 species and a single marine species, respectively. Although accidents with neurotoxic venoms are less frequent than those with anticoagulant, cytotoxic or necrotic venoms (e.g. from Bothrops), they are of major public health importance. Venoms from genus Crotalus have been extensively studied, while data on the venoms from the other two genera are very limited, especially for Hydrophis.

The venoms of North and South American Crotalus species show biochemical and physiopathological differ- ences. The former species cause bothrops-like envenomation symptoms, while the latter mainly have neurotoxic

and myotoxic effects, leading to respiratory paralysis and, occasionally, renal failure by myoglobinuria and death, often with no local lesions. Micrurus and Hydrophis also cause neurotoxic envenomations. Many studies have isolated, identified and characterized new enzymes and toxins, thus expanding the knowledge of snake venom composition. The present review summarizes the currently available information on neurotoxic venoms from South

American snakes, with a focus on protein composition and toxicological properties. It also includes some com- ments concerning potential medical applications of elapid and crotalic toxins.