Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina : a clinic and pathological correlation with special consideration on the central nervous system
Fecha
2012Autor
Ríos, Elvio Eduardo
Cholich, Luciana Andrea
Gimeno, Eduardo Juan
Guidi, María Guadalupe
Acosta, Ofelia Cristina
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Ipomoea carnea subsp. _istulosa, aguapei or mandiyura, is responsible for lysosomal storage in goats. The shrub contains several alkaloids, mainly swansonine which inhibits lysosomal α-mannosidase and Golgi mannosidase II. Poisoning occurs by inhibition of these hydrolases. There is neuronal vacuolation, endocrine dysfunction, cardiovascular and gastrointestinal injury, and immune disorders. Clinical signs and pathology of the experimental poisoning of goatsby Ipomoea carnea in Argentina are here described. Five goats received fresh leaves and stems of Ipomoea. At the beginning, the goats did not consume the plant, but later, it was preferred over any other forage. High dose induced rapid intoxication, whereas with low doses, the course of the toxicosis was more protracted. The goats were euthanized when they were recumbent. Cerebrum, cerebellum, medulla oblongata, pons and colliculi, were routinely processed for histology. In nine days, the following clinical signs developed: abnormal fascies, dilated nostrils and abnormal postures of the head, cephalic tremors and nystagmus, dif_iculty in standing. Subsequently, the goats had a tendency to fall, always to the left, with spastic convulsions.There was lack in coordination of voluntary movements due to Purkinje and deep nuclei neurons damage. The cochlear re_lex originated hyperre_lexia, abnormal posture, head movements and tremors. The withdrawal re_lex produced _lexor muscles hypersensitivity at the four legs, later depression and stupor. Abnormal responses to sounds were related to collicular lesions. Thalamic damage altered the withdrawal re_lex, showing incomplete reaction. The observed cervical hair bristling was attributed to a thalamic regulated nociceptive response. Depression may be associated with agonists of lysergic acid contained in Ipomoea. These clinical signs were correlated with lesions in different parts of the CNS. Ipomoea carnea subsp. fistulosa, aguapeí ou mandiyura, causa uma doenca de depósito lisossomal em caprinos. A planta contém vários alcalóides, principalmente swansonine, que inibe uma α-mannosidase lisossomal e uma mannosidase II do Golgi. A intoxicacao ocorre pela inibicao dessas hidrolases. Há vacuolizacao neuronal, disfuncao endocrina, lesoes cardiovasculares e gastrointestinais e disturbios imunologicos. No presente trabalho é descrita a intoxicacao experimental por Ipomoea carnea subsp. fistulosa em caprinos da Argentina. Cinco cabras receberam folhas frescas e ramos de Ipomoea. No comeco eles nao consumiram a planta, mas depois ela foi preferida a qualquer outras forrageiras. Altas doses induziram uma intoxicacao rápida, enquanto que com doses baixas demora mais tempo. As cabras foram sacri_icadas quando _icavam em decubito. Cérebro, cerebelo, medula oblonga, ponte e coliculos foram procesados rotineiramente para histologia. Aos nove dias, encontramos: fascie anormal, narinas dilatadas, posturas anormais da cabeca, tremores cefálicos e nistagmo, dificuldade para permanecer na estacao. Posteriormente, presentearam a tendencia de queda, sempre a esquerda, com convulsoes espasticas. Os neuronios de Purkinje e os os núcleos profundos foram dani_icados. Como consequencia, emergiu a falta de coordenacao de movimentos voluntarios. A hiper-reflexo coclear originou postura anormal, movimentos de cabeca e tremores. A retirada produz reflexos hipersensibilidade nos flexores dos quatro membros, depois depressao e letargia. As respostas anormais estao ligadas a lesoes do coliculo. Injurias no tálamo alteram o re_lexo de retirada, mostrando uma reacao incompleta. Os pelos ericados da regiao cervical podem representar uma resposta nociceptiva também regulada pelo talamo. A depressao pode estar associada com agonistas do ácido lisérgico presentes na Ipomoea. Esses sintomas estao relacionados com lesoes em diferentes partes do SNC.
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