Mostrar el registro sencillo del ítem
Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells
dc.contributor.author | Bustillo, Soledad | |
dc.contributor.author | Van de Velde, Andrea Carolina | |
dc.contributor.author | Matzner Perfumo, Verónica | |
dc.contributor.author | Gay, Claudia Carolina | |
dc.contributor.author | Leiva, Laura Cristina | |
dc.date.accessioned | 2021-12-09T16:27:23Z | |
dc.date.available | 2021-12-09T16:27:23Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Bustillo, Soledad, et al., 2017. Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells. Apoptosis. Suiza: Springer, vol. 22, no. 4, p. 491-501.ISSN 1360-8185. | es |
dc.identifier.issn | 1360-8185 | es |
dc.identifier.uri | http://repositorio.unne.edu.ar/handle/123456789/30330 | |
dc.description.abstract | In this study, the apoptosis inducing effects of baltergin as well as its influence on cell adhesion and migration on muscles cells in vitro were studied. Morphological analysis made by scanning electron and pase contrast microscopy demonstrated typical futures of programmed cell death, apoptosis. This mechanism was confirmed by fluorescence staining, molecular analysis of endonuclease activity and increased mRNA expresión level of two representative genes (p53 and bax). On the other hand, baltergin exert an inhibition effect on myoblast cell adhesion and migration in vitro probably through a mechanism that involves the interaction of this enzyme with cell integrins. In conclusion, our results suggest that the absence of appropriate extracellular matrix contacts triggers anoikis. Therefore, this is the first report that demonstrated the mechanism of programmed cell death triggered by baltergin, a PIII metalloprotease isolated from Bothrops alternatus venom, in a myoblast cell line. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Springer | es |
dc.rights | openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | es |
dc.source | Apoptosis, 2017, vol. 22, no. 4, p. 491-501. | es |
dc.subject | Baltergin | es |
dc.subject | Metalloproteinase | es |
dc.subject | Bothrops alternatus | es |
dc.subject | Anoikis | es |
dc.subject | Apoptosis | es |
dc.title | Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells | es |
dc.type | Artículo | es |
unne.affiliation | Fil: Bustillo, Soledad. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina | es |
unne.affiliation | Fil: Van de Velde, Andrea Carolina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina. | es |
unne.affiliation | Fil: Van de Velde, Andrea Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. | es |
unne.affiliation | Fil: Matzner Perfumo, Verónica. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina. | es |
unne.affiliation | Fil: Gay, Claudia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina. | es |
unne.affiliation | Fil: Gay, Claudia Carolina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina | es |
unne.affiliation | Fil: Leiva, Laura Cristina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina | es |
unne.journal.pais | Suiza | es |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Artículos de revista [673]