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Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death
dc.contributor.author | Rodríguez, Juan Pablo | |
dc.contributor.author | Guijas, Carlos | |
dc.contributor.author | Astudillo del Valle, Alma María | |
dc.contributor.author | Rubio, Julio Miguel | |
dc.contributor.author | Balboa, María Ángeles | |
dc.contributor.author | Balsinde, Jesús | |
dc.date.accessioned | 2021-06-09T21:43:52Z | |
dc.date.available | 2021-06-09T21:43:52Z | |
dc.date.issued | 2019-04-12 | |
dc.identifier.citation | Rodríguez, Juan Pablo, et.al., 2019. Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death. Cancers. Barcelona: Multidisciplinary Digital Publishing Institute, vol. 11, no. 524, p. 1-15. ISSN 2072-6694. | es |
dc.identifier.issn | 2072-6694 | es |
dc.identifier.uri | http://repositorio.unne.edu.ar/handle/123456789/28103 | |
dc.description.abstract | Hydroxy fatty acids are known to cause cell cycle arrest and apoptosis. The best studied of them, 9-hydroxystearic acid (9-HSA), induces apoptosis in cell lines by acting through mechanisms involving different targets. Using mass spectrometry-based lipidomic approaches, we show in this study that 9-HSA levels in human colorectal tumors are diminished when compared with normal adjacent tissue. Since this decrease could be compatible with an escape mechanism of tumors from 9-HAS induced apoptosis, we investigated different features of the utilization of this hydroxyl fatty acid in colon. We show that in colorectal tumors and related cell lines such as HT-29 and HCT-116, 9-HSA is the only hydroxyl fatty acid constituent of branched fatty acid esters of hydroxyl fatty acids (FAHFA), a novel family of lipids with anti-inflammatory properties. Importantly, FAHFA levels in tumors are elevated compared with normal tissue and, unlike 9-HSA, they do not induce apoptosis of colorectal cell lines over a wide range of concentrations. Further, the addition of 9-HSA to colon cancer cell lines augments the synthesis of different FAHFA before the cells commit to apoptosis, suggesting that FAHFA formation may function as a buffer system that sequesters the hydroxyacidinto an inactive form, thereby restricting apoptosis. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute | es |
dc.rights | openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | es |
dc.source | Cancers, 2019, vol. 11, no. 524, p. 1-15. | es |
dc.subject | Colorectal cancer | es |
dc.subject | Hydroxystearic acid | es |
dc.subject | Fatty acid esters of hydroxy fatty | es |
dc.subject | Fatty acid esters of hydroxy fatty acids | es |
dc.subject | Apoptosis | es |
dc.title | Sequestration of 9-hydroxystearic acid in fahfa (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death | es |
dc.type | Artículo | es |
unne.affiliation | Fil: Rodríguez, Juan Pablo. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. | es |
unne.affiliation | Fil: Rodríguez, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Nordeste; Argentina. | es |
unne.affiliation | Fil: Guijas, Carlos. Universidad de Valladolid. Consejo Superior de Investigaciones Científicas. Instituto de Biología y Genética Molecular; España. | es |
unne.affiliation | Fil: Guijas, Carlos. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España. | es |
unne.affiliation | Fil: Astudillo del Valle, Alma María. Universidad de Valladolid. Consejo Superior de Investigaciones Científicas. Instituto de Biología y Genética Molecular; España. | es |
unne.affiliation | Fil: Astudillo del Valle, Alma María. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España. | es |
unne.affiliation | Fil: Rubio, Julio Miguel. Universidad de Valladolid. Consejo Superior de Investigaciones Científicas. Instituto de Biología y Genética Molecular; España. | es |
unne.affiliation | Fil: Rubio, Julio Miguel. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España. | es |
unne.affiliation | Fil: Balboa, María Ángeles. Universidad de Valladolid. Consejo Superior de Investigaciones Científicas. Instituto de Biología y Genética Molecular; España. | es |
unne.affiliation | Fil: Balboa, María Ángeles. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España. | es |
unne.affiliation | Fil: Balsinde, Jesús. Universidad de Valladolid. Consejo Superior de Investigaciones Científicas. Instituto de Biología y Genética Molecular; España. | es |
unne.affiliation | Fil: Balsinde, Jesús. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España. | es |
unne.journal.pais | España | es |
unne.journal.ciudad | Barcelona | es |
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