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dc.contributor.authorHeitrich, Mauro
dc.contributor.authorGarcía, Daiana Maria de los Ángeles
dc.contributor.authorStoyanoff, Tania Romina
dc.contributor.authorRodríguez, Juan Pablo
dc.contributor.authorTodaro, Juan Santiago
dc.contributor.authorAguirre, María Victoria
dc.date.accessioned2022-05-19T14:40:09Z
dc.date.available2022-05-19T14:40:09Z
dc.date.issued2016
dc.identifier.citationHeitrich, Mauro, et al., 2016. Erythropoietin attenuates renal and pulmonary injury in polymicrobial induced-sepsis through EPO-R, VEGF and VEGF-R2 modulation. Biomedicine & Pharmacotherapy. Ámsterdam: Elsevier, vol. 82, p. 603-616. ISSN 0753-3322.es
dc.identifier.issn0753-3322es
dc.identifier.urihttp://repositorio.unne.edu.ar/handle/123456789/47782
dc.description.abstractSepsis remains the most important cause of acute kidney injury (AKI) and acute lung injury (ALI) in critically ill patients. The cecal ligation and puncture (CLP) model in experimental mice reproduces most of the clinical features of sepsis. Erythropoietin (EPO) is a well-known cytoprotective multifunctional hormone, which exerts anti-inflammatory, anti-oxidant, anti-apoptotic and pro-angiogenic effects in several tissues. The aim of this study was to evaluate the underlying mechanisms of EPO protection through the expression of the EPO/EPO receptor (EPO-R) and VEGF/VEF-R2 systems in kidneys and lungs of mice undergoing CLP-induced sepsis. Male inbred Balb/c mice were divided in three experimental groups: Sham, CLP, and CLP + EPO (3000 IU/kg sc). Assessment of renal functional parameters, survival, histological examination, immunohistochemistry and/or Western blottings of EPO-R, VEGF and VEGF-R2 were performed at 18 h post-surgery. Mice demonstrated AKI by elevation of serum creatinine and renal histologic damage. EPO treatment attenuates renal dysfunction and ameliorates kidney histopathologic changes. Additionally, EPO administration attenuates deleterious septic damage in renal cortex through the overexpression of EPO-R in tubular interstitial cells and the overexpression of the pair VEGF/VEGF-R2. Similarly CLP- induced ALI, as evidenced by parenchymal lung histopathologic alterations, was ameliorated through pulmonary EPO-R, VEGF and VEGF-R2 over expression suggesting and improvement in endothelial survival and functionality. This study demonstrates that EPO exerts protective effects in kidneys and lungs in mice with CLPinduced sepsis through the expression of EPO-R and the regulation of the VEGF/VEGF-R2 pair.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rightsopenAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/es
dc.sourceBiomedicine & Pharmacotherapy, 2016, vol. 38, p. 603-616.es
dc.subjectCecal ligation and puncture (CLP)es
dc.subjectSepsis Erythropoietin (EPO)es
dc.subjectAcute lung injury (ALI)es
dc.subjectAcute kidney injury (AKI)es
dc.titleErythropoietin attenuates renal and pulmonary injury in polymicrobial induced-sepsis through EPO-R, VEGF and VEGF-R2 modulationes
dc.typeArtículoes
unne.affiliationFil: Heitrich, Mauro. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.es
unne.affiliationFil: Stoyanoff, Tania Romina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.es
unne.affiliationFil: Rodríguez, Juan Pablo. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.es
unne.affiliationFil: Todaro, Juan Santiago. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.es
unne.affiliationFil: Aguirre, María Victoria. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina.es
unne.journal.paisPaíses Bajoses
unne.journal.ciudadÁmsterdames


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